The cholinergic anti-inflammatory pathway alleviates acute lung injury
نویسندگان
چکیده
منابع مشابه
Acute vagotomy activates the cholinergic anti-inflammatory pathway.
Francis, Joseph, Shun-Guang Wei, Robert M. Weiss, and Robert B. Felder. Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol 287: H791–H797, 2004; doi:10.1152/ajpheart.00099.2004.— Within minutes of acute myocardial infarction (MI), proinflammatory cytokines increase in the brain, heart, and plasma. We hypothesized that cardi...
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Inflammatory responses are associated with the genesis and progression of end-organ damage (EOD) in hypertension. A role for the 7 nicotinic acetylcholine receptor ( 7nAChR) in inflammation has recently been identified. We tested the hypothesis that 7nAChR dysfunction contributes to hypertensive EOD. In both spontaneously hypertensive rats (SHRs) and rats with abdominal aorta coarctation–induce...
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Innate immune responses and inflammation are regulated in part by neural mechanisms. In the present paper, we summarize experimental evidence that reveals that innate immunity and inflammation are controlled by the vagus nerve, previously known as a regulator of other vital physiological functions. Activation of vagus nerve cholinergic signalling inhibits TNF (tumour necrosis factor) and other ...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2020
ISSN: 1076-1551,1528-3658
DOI: 10.1186/s10020-020-00184-0